|
KMID : 0895820120220030065
|
|
Journal of Oriental Rehabilitation Medicine
2012 Volume.22 No. 3 p.65 ~ p.78
|
|
|
Effects of Ethanol Extract from Sodok -eum on UVB-induced Damage in Human Keratinocyte HaCaT Cells
|
|
Jun Kyu-Sang
Kim Il-Hyun
Lim Gwang-Mook
Song Yuug-Sun
|
|
|
Abstract
|
|
|
Objectives :Sodok-eum(xiaodu-yˇln, SDU) exhibits potent anti-inflammatory activity with an unknown mechanism. The purpose of this study is to elucidate the molecular mechanisms of SDU on pharmacological and biochemical actions in inflammation.
Methods :We examined the effect of SDU on pro-inflammatory mediators in lipopolysaccharide(UVB)-stimulated HaCaT. The investigation focused on whether SDU inhibited cyclooxygenase-2(COX-2), interleukin-6(IL-6), interleukin-8(IL-8) and mitogen-activated protein kinases(MAPKs) in UVB-stimulated HaCaT cells.
Results :SDU inhibited UVB-induced IL-6, IL-8 productions as well as the expressions of COX-2. Furthermore, SDU suppressed the UVB-induced phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2), c-JUN N-terminal kinase 1/2(JNK 1/2), p38.
Conclusions :These results suggest that SDU has inhibitory effects on UVB-induced IL-6, IL-8 production, as well as the expressions of COX-2 in the HaCaT. The inhibitory effects occur through blockades on the phosphorylation of MAPKs following activation.
|
|
|
KEYWORD
|
|
|
Sodok-eum(xiaodu-yˇln), UVB, HaCaT, COX-2, IL-6, IL-8, MAPKs
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|